Nicotine diminishes anticonvulsant activity of antiepileptic drugs in mice.
نویسندگان
چکیده
Nicotine administered acutely at subconvulsive dose of 4 mg/kg, significantly decreased the protective activity of valproate, carbamazepine, diphenylhydantoin, phenobarbital, topiramate and lamotrigine against maximal electroshock-induced tonic convulsions in mice. The obtained data may suggest that interaction between nicotine and antiepileptic drugs should be carefully considered as a cause of the therapeutic failure in epileptic patients.
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ورودعنوان ژورنال:
- Polish journal of pharmacology
دوره 55 5 شماره
صفحات -
تاریخ انتشار 2003